Article

Computationally Designed RNA Aptamers Enable Selective Detection of FUS Pathology in ALS

2025-04-30

Abstract excerpt

<h4>ABSTRACT</h4> FUS is an RNA/DNA-binding protein whose mislocalization and aggregation are defining pathological features of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Detecting pathological FUS assemblies remains challenging, as antibody-based approaches are frequently limited by epitope masking, conformational heterogeneity, and cross-reactivity with physiological FUS p...

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Literature Corpus work: ac273dee-ab79-5ea5-a3e9-9abb1dde0918
DOI: 10.1101/2025.04.30.651570

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