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Article

Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.

Nature communications - 11 Dec 2020

Jutzi Daniel, Campagne Sébastien, Schmidt Ralf, Reber Stefan, Mechtersheimer Jonas, Gypas Foivos, Schweingruber Christoph, Colombo Martino, von Schroetter Christine, Loughlin Fionna E, Devoy Anny, Hedlund Eva, Zavolan Mihaela, Allain Frédéric H-T, Ruepp Marc-David

Abstract excerpt

Mutations in the RNA-binding protein Fused in Sarcoma (FUS) cause early-onset amyotrophic lateral sclerosis (ALS). However, a detailed understanding of central RNA targets of FUS and their implications for disease remain elusive. Here, we use a unique blend of crosslinking and immunoprecipitation (CLIP) and NMR spectroscopy to identify and characterise physiological and pathological RNA targets of FUS. We find...

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Identifiers

PMID: 33311468
DOI: 10.1038/s41467-020-20191-3
PMCID: PMC7733473

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Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.PMID 33311468Read ↗

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