Article

RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with <i>STMN-2</i> cryptic splicing and precedes clinical manifestation in ALS

2023-10-27

Abstract excerpt

TDP-43 is an aggregation-prone protein which accumulates in the hallmark pathological inclusions of amyotrophic lateral sclerosis (ALS). However, analysis of deeply-phenotyped human post-mortem samples has shown that TDP-43 aggregation, revealed by standard antibody methods, correlates poorly with symptom manifestation. Recent identification of cryptic-splicing events, such as the detection of Stathmin-2 ( STMN...

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Literature Corpus work: dfaa4816-68ed-5426-81b4-8bfe2645f676
DOI: 10.1101/2023.10.24.563701

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