Article

Computationally Designed RNA Aptamers Enable Selective Detection of FUS Pathology in ALS

2026-02-11

Abstract excerpt

<title>Abstract</title> <p>FUS is an RNA/DNA-binding protein whose mislocalization and aggregation are defining pathological features of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Detecting pathological FUS assemblies remains challenging, as antibody-based approaches are frequently limited by epitope masking, conformational heterogeneity, and cross-reactivity with physiologi...

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Literature Corpus work: 7955010a-6b8b-55fb-ab25-47f733352bb5
DOI: 10.21203/rs.3.rs-8435730/v1

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