Back to search

Article

SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes

2020-09-25

Abstract excerpt

<h4>Summary</h4> Coronaviruses are adept at evading host antiviral pathways induced by viral double-stranded RNA, including interferon (IFN) signaling, oligoadenylate synthetase–ribonuclease L (OAS-RNase L), and protein kinase R (PKR). While dysregulated or inadequate IFN responses have been associated with severe coronavirus infection, the extent to which the recently emerged SARS-CoV-2 activates or antagonizes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ac24c79f-c1a6-50b4-99cb-db40b50a02f5
DOI
10.1101/2020.09.24.312553
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytesDOI 10.1101/2020.09.24.312553
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytesSemantic proximity
An Endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cellsSemantic proximity
Comprehensive comparison of transcriptomes in SARS-CoV-2 infection: alternative entry routes and innate immune responsesSemantic proximity
SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory ResponseSemantic proximity
Type I interferon signaling induces a delayed antiproliferative response in Calu-3 cells during SARS-CoV-2 infectionSemantic proximity
SARS-CoV-2 replication triggers an MDA-5-dependent interferon production which is unable to efficiently control replicationSemantic proximity
Parallel use of pluripotent human stem cell lung and heart models provide new insights for treatment of SARS-CoV-2Semantic proximity
Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infectionSemantic proximity
SARS-CoV-2 Triggers an MDA-5-Dependent Interferon Response Which Is Unable To Control Replication in Lung Epithelial CellsSemantic proximity
SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory ResponseSemantic proximity
Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gutSemantic proximity
Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2Semantic proximity
Select a neighboring publication to make it the new centre.