Article

Covid-Associated Pernio is the Product of an Abortive Sars-Cov-2 Infection Resulting in the Deposition of Inflammatory Viral Rna and a Local Interferon Response

2022-08-31

Abstract excerpt

SARS-CoV-2 replicates primarily in the airways but generates a systemic immune response mediated by Type I interferons (IFN-I). Pernio is a rare skin manifestation of monogenic disorders characterized by excessive IFN-I signaling. Although pernio increased in incidence during the pandemic, direct SARS-CoV-2 involvement in “COVID toes” remains controversial. To further assess COVID-associated pernio, we characteri...

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Literature Corpus work: abf39744-001a-5c30-bbc0-f4297b770493
DOI: 10.2139/ssrn.4197401

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