Article

Microbiota-derived short chain fatty acids promote Aβ plaque deposition

2020-06-10

Abstract excerpt

Previous studies have identified a crucial role of the gut microbiome in modifying Alzheimer’s disease (AD) progression. However, the mechanisms of microbiome-brain interaction in AD, including the microbial mediators and their cellular targets in the brain, were so far unknown. Here, we identify microbiota-derived short chain fatty acids (SCFA) as key metabolites along the gut-brain axis in AD. Germ-free (GF) AD...

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Literature Corpus work: ab58391f-87ab-5e43-9c47-b4d68210f2d6
DOI: 10.1101/2020.06.09.141879

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