Article

Mutational pressure drives enhanced release of proteasome-generated public CD8<sup>+</sup>T cell epitopes from SARS-CoV-2 RBD of Omicron and its current lineages

2024-04-03

Abstract excerpt

<h4>SUMMARY</h4> The COVID-19 pandemic was the most dramatic in the newest history with nearly 7 million deaths and global impact on mankind. Here we report binding index of 305 HLA class I molecules from 18,771 unique haplotypes of 28,104 individuals to 821 peptides experimentally observed from spike protein RBD of 5 main SARS-CoV-2 strains hydrolyzed by human proteasomes with constitutive and immune catalytic ph...

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Literature Corpus work: 10f9a947-e331-5d60-a92e-f3fe89541df3
DOI: 10.1101/2024.04.03.24305074

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