Article

ACE2 mimetic antibody potently neutralizes all SARS-CoV-2 variants and fully protects in XBB.1.5 challenged monkeys

2023-07-18

Abstract excerpt

The rapid evolution of SARS-CoV-2 to variants with improved transmission efficiency and reduced sensitivity to vaccine-induced humoral immunity has abolished the protective effect of licensed therapeutic human monoclonal antibodies (mAbs). To fill this unmet medical need and protect vulnerable patient populations, we isolated the P4J15 mAb from a previously infected, vaccinated donor, with <20 ng/ml neutralizing a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ab146117-f8ac-5fd1-be0b-08ed11c17ac3
DOI: 10.1101/2023.07.18.549530

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ACE2 mimetic antibody potently neutralizes all SARS-CoV-2 variants and fully protects in XBB.1.5 challenged monkeysDOI 10.1101/2023.07.18.549530Read

Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeysSemantic proximity Read

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variantsSemantic proximity Read

Assessment of neutralization susceptibility of Omicron subvariants XBB.1.5 and BQ.1.1 against broad-spectrum neutralizing antibodies through epitopes mappingSemantic proximity Read

Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeysSemantic proximity Read

An engineered ACE2 decoy broadly neutralizes Omicron subvariants and shows therapeutic effect in SARS-CoV-2-infected cynomolgus macaquesSemantic proximity Read

Neutralization, effector function and immune imprinting of Omicron variants.Semantic proximity Read

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicrySemantic proximity Read

Therapeutic and vaccine-induced cross-reactive antibodies with effector function against emerging Omicron variantsSemantic proximity Read

Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variantSemantic proximity Read

An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitopeSemantic proximity Read

Potent, Omicron-Neutralizing Antibodies Isolated From a Patient Vaccinated 6 Months Before Omicron EmergenceSemantic proximity Read

Neutralization escape of Omicron XBB, BR.2, and BA.2.3.20 subvariants.Semantic proximity Read