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Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant

8 Feb 2024

Abstract excerpt

Circulation of SARS-CoV-2 Omicron XBB has resulted in the emergence of XBB.1.5, a new Variant of Interest. Our phylogenetic analysis suggests that XBB.1.5 evolved from XBB.1 by acquiring the S486P spike (S) mutation, subsequent to the acquisition of a nonsense mutation in ORF8. Neutralization assays showed similar abilities of immune escape between XBB.1.5 and XBB.1. We determine the structural basis for the...

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PMID: 38332154
DOI: 10.1038/s41467-024-45274-3

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