Article

Molecular Dynamics Study of α-Synuclein Domain Deletion Mutant Monomers

2024-03-27

Abstract excerpt

Aggregates of misfolded α-synuclein proteins (asyn) are key markers of Parkinson’s disease. Asyn proteins have three domains: an N-terminal domain, a hydrophobic NAC core implicated in aggregation, and a proline-rich C-terminal domain. Proteins with truncated C-terminal domains are known to be prone to aggregation and suggest that understanding domain-domain interactions in asyn monomers could help elucidate the r...

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Literature Corpus work: aa584b1f-a070-5e48-87d3-b2aba4cf522e
DOI: 10.1101/2024.03.23.586267

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