Article

Pan-cancer analysis of patient tumor single-cell transcriptomes identifies promising selective and safe CAR targets in head and neck cancer

2021-10-01

Abstract excerpt

BACKGROUND: Chimeric antigen receptor (CAR) T cell therapies have yielded transformative clinical success for patients with blood tumors, but their full potential remains to be unleashed against solid tumors. One challenge is finding selective targets: cell surface proteins that are expressed widely by cancer cells and minimally by healthy cells in the tumor microenvironment and other normal tissues. METHODS: Ana...

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Literature Corpus work: aa3295c5-8cad-5f97-9d1c-88a1a6d6ead0
DOI: 10.1101/2021.09.29.462485

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