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Spatial Rewiring of Enterocyte Identity in Celiac Disease

2026-02-17

Abstract excerpt

Enterocytes in the human small intestine exhibit distinct functional states in different zones along the crypt-villus axis, a feature that is thought to convey optimal absorption. In celiac disease (CeD), autoimmune destruction of enterocytes leads to villus blunting, but how this altered tissue morphology affects enterocyte states is unclear. Using spatial and single-cell transcriptomics, we show that in patients...

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Literature Corpus work
a9d2b15d-cd3a-5ff4-bd19-8bdbdbb37c4f
DOI
10.64898/2026.02.14.705877
Open publication

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Spatial Rewiring of Enterocyte Identity in Celiac DiseaseDOI 10.64898/2026.02.14.705877
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