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Article

CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection.

mBio - 6 Feb 2018

Lee Jennifer S, Raja Priya, Pan Dongli, Pesola Jean M, Coen Donald M, Knipe David M

Abstract excerpt

Herpes simplex virus 1 (HSV-1) establishes latent infection in neurons via a variety of epigenetic mechanisms that silence its genome. The cellular CCCTC-binding factor (CTCF) functions as a mediator of transcriptional control and chromatin organization and has binding sites in the HSV-1 genome. We constructed an HSV-1 deletion mutant that lacked a pair of CTCF-binding sites (CTRL2) within the latency-associated...

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Identifiers

PMID: 29437926
DOI: 10.1128/mBio.02372-17
PMCID: PMC5801469

Genes

CTCF
LAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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