Article

KSHV genome harbors both constitutive and lytically induced enhancers

2024-01-31

Abstract excerpt

Kaposi’s sarcoma-associated herpesvirus (KSHV) belongs to the gamma-herpesvirus family and is a well-known human oncogenic virus. In infected cells, the viral genome of 165 kbp is circular DNA wrapped in chromatin. The tight control of gene expression is critical for latency, the transition into the lytic phase, and the development of viral-associated malignancies. Distal cis-regulatory elements (CRE), such as enh...

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Literature Corpus work: 93106d42-7f0a-5cb5-a2f8-3a2fe28d4b72
DOI: 10.1101/2024.01.30.577957

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