Article
Identification of epigenetic signature associated with alpha thalassemia/mental retardation X-linked syndrome.
Epigenetics & chromatin - 1 Jan 2017
Schenkel Laila C, Kernohan Kristin D, McBride Arran, Reina Ditta, Hodge Amanda, Ainsworth Peter J, Rodenhiser David I, Pare Guillaume, Bérubé Nathalie G, Skinner Cindy, Boycott Kym M, Schwartz Charles, Sadikovic Bekim
Abstract excerpt
BACKGROUND: Alpha thalassemia/mental retardation X-linked syndrome (ATR-X) is caused by a mutation at the chromatin regulator gene ATRX. The mechanisms involved in the ATR-X pathology are not completely understood, but may involve epigenetic modifications. ATRX has been linked to the regulation of histone H3 and DNA methylation, while mutations in the ATRX gene may lead to the downstream epigenetic and...
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