Article

Two Substrates, One Switch: Oxygen and Iodine as the Mechanistic Basis of the Three-Armed HIF-1α Severity Cascade in SARS-CoV-2 Infection

2026-04-07

Abstract excerpt

Severe COVID-19 follows a cliff-edge trajectory: patients appear stable, then deteriorate rapidly and irreversibly. This paper identifies molecular oxygen as the dual control variable governing two previously unconnected biological systems: the DUOX-Lactoperoxidase-Iodine (DLI) airway antiviral defense and HIF-1α, the transcription factor that drives COVID-19 severity. Both share the same oxygen-dependent enzymes...

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Literature Corpus work: a9ac9131-c208-57c0-ac51-617840cc2d95
DOI: 10.20944/preprints202604.0439.v1

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