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Identification of HIF1A as a therapeutic target during SARS-CoV-2–associated lung injury

17 Jun 2025

Abstract excerpt

Hypoxia-inducible factors (HIFs) promote lung protection and pathogen eradication during acute lung injury. We, therefore, tested the theory that pharmacologic stabilization of HIFs dampens lung injury during SARS-CoV-2 pneumonia. Initial studies in murine SARS-CoV-2 models showed improved outcomes after treatment with the FDA-approved HIF stabilizer vadadustat. Subsequent studies in genetic models implicated...

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PMID: 40526427
DOI: 10.1172/jci.insight.191463

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