Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multi-omics identifies oxidative stress, prothrombotic pathways, and lactoperoxidase variants as key factors in COVID-19 severity.

EBioMedicine - 1 Jan 2026

Cappadona Claudio, Rimoldi Valeria, Tettamanzi Francesca, Cardamone Giulia, Mantovani Alberto, Soldà Giulia, Paraboschi Elvezia Maria, Asselta Rosanna

Abstract excerpt

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected over 26 million individuals in Italy, resulting in ∼200,000 COVID-19-related deaths. Unravelling host genetic factors underlying disease severity is key to understanding progression mechanisms. METHODS: We applied multi-omics approaches to investigate genetic susceptibility to COVID-19 severity in the Italian population. We combined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to COVID-19

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Multiomics

Share to Oxidative Stress

Share to SARS-CoV-2

Share to Severity of Illness Index

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 41500120
DOI: 10.1016/j.ebiom.2025.106111
PMCID: PMC12809084

Genes

LPO
MTERF1
TDP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi-omics identifies oxidative stress, prothrombotic pathways, and lactoperoxidase variants as key factors in COVID-19 severity.PMID 41500120Read ↗

Presence of rare potential pathogenic variants in subjects under 65 years old with very severe or fatal COVID-19.Semantic proximity Read ↗

Superoxide dismutase alterations in COVID-19: implications for disease severity and mortality prediction in the context of omicron variant infectionSemantic proximity Read ↗

GWAS and meta-analysis identifies multiple new genetic mechanisms underlying severe Covid-19Semantic proximity Read ↗

Whole genome sequencing identifies multiple loci for critical illness caused by COVID-19Semantic proximity Read ↗

Whole-genome sequencing reveals host factors underlying critical COVID-19Semantic proximity Read ↗

Employing a systematic approach to biobanking and analyzing clinical and genetic data for advancing COVID-19 research.Semantic proximity Read ↗

Employing a Systematic Approach to Biobanking and Analyzing Clinical and Genetic Data for Advancing COVID-19 ResearchSemantic proximity Read ↗

Genes associated with liver damage signalling pathways may impact the severity of COVID-19 symptoms in Spanish and Italian populationsSemantic proximity Read ↗

Genetic determinants of metabolic-inflammatory dysregulation and machine learning prediction of COVID-19.Semantic proximity Read ↗

Polyunsaturated fatty acid-derived lipid mediator networks characterize COVID-19 severity and risk for critical illnessSemantic proximity Read ↗

Association Between the LZTFL1 rs11385942 Polymorphism and COVID-19 Severity in Colombian PopulationSemantic proximity Read ↗

Dysregulation of redox-inflammatory markers in COVID-19: A multi-parameter analysis with disease severitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.