Role of SCN5A coding and non-coding sequences in Brugada syndrome onset: What’s behind the scenes?

Abstract excerpt

Brugada syndrome (BrS) is a rare inherited cardiac arrhythmia associated with a high risk of sudden cardiac death (SCD) due to ventricular fibrillation (VF). BrS is characterized by coved-type ST-segment elevation in the right precordial leads (V1-V3) in the absence of structural heart disease. This pattern is spontaneous, or is unmasked by intravenous administration of Class I antiarrhythmic drugs. The SCN5A-enco...

Topics

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• Brugada Syndrome
• Cardiac electrophysiology and arrhythmias
• Death, Sudden, Cardiac
• Genetic Association Studies
• Genetic Testing
• Genotype
• Mutation
• NAV1.5 Voltage-Gated Sodium Channel

Identifiers and source

Literature Corpus work

ff2a105a-7b14-5499-b119-5225ea42b511

DOI

10.1101/218099