Article

Three New Potent HIV-1 Inhibitors from Myxobacteria

1992-08-01

Abstract excerpt

Three novel compounds, namely, phenoxan, phenalamide A1, and thiangazole, were found to suppress HIV-1 replication in cell cultures. The compounds were discovered by screening crude extracts from myxobacteria and were isolated from two strains of Polyangium sp. and a strain of Myxococcus stipitatus. Their structures have been elucidated. The cytotoxic concentrations for MT-4 cells were 6.6 μM for phenoxan, 102 μM...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a8a775a4-18b8-5c09-808d-457c14a419ce
DOI: 10.1177/095632029200300401

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Three New Potent HIV-1 Inhibitors from MyxobacteriaDOI 10.1177/095632029200300401Read

Identification of myxobacteria-derived HIV inhibitors by a high-throughput two-step infectivity assaySemantic proximity Read

Tetrahydronaphthalene lignan compounds as potent anti-HIV type 1 agents.Semantic proximity Read

In vitro selective elimination of HIV-infected cells from peripheral blood in AIDS patients by the immunotoxin DAB389CD4.Semantic proximity Read

Anti-human immunodeficiency virus 1 (HIV-1) activities of 3-deazaadenosine analogs: increased potency against 3'-azido-3'-deoxythymidine-resistant HIV-1 strains.Semantic proximity Read

Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2'-deoxy-3'-thiacytidine (BCH-189), a novel heterocyclic nucleoside analogSemantic proximity Read

Chloroquine inhibits HIV-1 replication in human peripheral blood lymphocytesSemantic proximity Read

Thalidomide and thalidomide analogs reduce HIV type 1 replication in human macrophages in vitro.Semantic proximity Read

Myxobacterial secondary metabolites: bioactivities and modes-of-actionSemantic proximity Read