Article
Thalidomide and thalidomide analogs reduce HIV type 1 replication in human macrophages in vitro.
AIDS research and human retroviruses - 1 Jul 1997
Moreira A L, Corral L G, Ye W, Johnson B, Stirling D, Muller G W, Freedman V H, Kaplan G
Abstract excerpt
Thalidomide is currently being evaluated for efficacy in alleviating some manifestations of HIV-1 infection. To determine whether thalidomide has any direct effects on HIV-1 infection, we investigated the effect of thalidomide and also of three structural analogs of thalidomide on HIV-1 replication in vitro in human monocyte-derived macrophages. The thalidomide analogs were previously shown to inhibit TNF-alpha...
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