Article
Quinoxapeptins: novel chromodepsipeptide inhibitors of HIV-1 and HIV-2 reverse transcriptase. I. The producing organism and biological activity.
The Journal of antibiotics - 1 Mar 1996
Lingham R B, Hsu A H, O'Brien J A, Sigmund J M, Sanchez M, Gagliardi M M, Heimbuch B K, Genilloud O, Martin I, Diez M T, Hirsch C F, Zink D L, Liesch J M, Koch G E, Gartner S E, Garrity G M, Tsou N N, Salituro G M
Abstract excerpt
Quinoxapeptin A and B are novel chromodepsipeptides which were isolated from a nocardioform actinomycete with indeterminant morphology. Quinoxapeptins A and B are potent inhibitors of HIV-1 and HIV-2 reverse transcriptase and almost equally active against two single mutants forms as well as a double mutant form of HIV-1 reverse transcriptase. Quinoxapeptin A and B are specific inhibitors of HIV-1 and HIV-2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.