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Tetrahydronaphthalene lignan compounds as potent anti-HIV type 1 agents.

AIDS research and human retroviruses - 20 May 1997

Hara H, Fujihashi T, Sakata T, Kaji A, Kaji H

Abstract excerpt

Anti-HIV-1 activity of tetrahydronaphthalene (THN) derivatives of lignan compounds was studied. THN derivatives prevented cell death caused by HIV-1 infection in MT-4 cells. They also inhibited giant cell formation by HIV-1 in Sup-T1 cells, and p24 production in HIV-1-infected H9 cells. The 50% effective concentration (ED50) of the most active compound, 1737...

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PMID: 9168238
DOI: 10.1089/aid.1997.13.695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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