Article

Myelin Supports Cortical Circuit Function Underlying Skilled Movement

2025-12-24

Abstract excerpt

Primary motor cortex (M1) is among the most heavily myelinated cortical regions and generates tightly coordinated neuronal activity patterns that drive skilled movement. Activity-dependent myelination is required for motor skill acquisition, and myelin loss in demyelinating diseases such as multiple sclerosis leads to motor impairment. Yet how myelination influences neuronal activity underlying skilled behavior re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a874c3cc-7514-564c-9ae2-b1479ed7dbd3
DOI: 10.64898/2025.12.23.696289

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Myelin Supports Cortical Circuit Function Underlying Skilled MovementDOI 10.64898/2025.12.23.696289Read

Motor Learning Promotes Remyelination via New and Surviving OligodendrocytesSemantic proximity Read

Automated in vivo tracking of cortical oligodendrocytesSemantic proximity Read

Patterns of Structural Disconnection Driving Proprioceptive Deficits After StrokeSemantic proximity Read

Decomposing cognitive-motor planning from execution: smartphone motor sequencing provides scalable digital biomarkers of cognitive-motor function across central nervous system disordersSemantic proximity Read

A Proposed Cause, Cure, and Mechanism for Focal Task-Specific Dystonia: A Theoretical-Empirical ApproachSemantic proximity Read

Emergence of Task-Related Motor Cortical Dysfunction in Mice with Progressive ParkinsonismSemantic proximity Read

Functional Myelin in Cognition and Neurodevelopmental DisordersSemantic proximity Read

Pathophysiology of voluntary motor commands at the level of the spinal motoneuron in patients with multiple sclerosisSemantic proximity Read

Local demyelination rekindles oligodendrocyte precursor dynamics and remyelination in old ageSemantic proximity Read

Emerging ideas and tools to study the emergent properties of the cortical neural circuits for voluntary motor control in non-human primatesSemantic proximity Read

Reversible Loss of Hippocampal Function in a Mouse Model of Demyelination/RemyelinationSemantic proximity Read

Structure-Function Coupling Aligns with a Unimodal-to-Transmodal Gradient in the Mouse CortexSemantic proximity Read