Article

Zoliflodacin and gepotidacin cross-resistance in <i>Neisseria gonorrhoeae</i>

2025-11-25

Abstract excerpt

Resistance to zoliflodacin, a first-in-class antibiotic for gonorrhea treatment, can occur through gyrB D429N , but this mutation’s impact on fitness and resistance to other topoisomerase targeting drugs, including gepotidacin, have been unclear. Here, we show that gyrB D429N confers cross-resistance to gepotidacin in some clinical isolates and that its fitness effect varies with strain back-ground. These findin...

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Literature Corpus work: a8747fad-2117-529a-a139-c21c83fc7011
DOI: 10.1101/2025.11.25.690462

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