Article

Modeling the dynamics of Let-7-coupled gene regulatory networks linking cell proliferation to malignant transformation

2019-01-13

Abstract excerpt

The microRNA Let-7 controls the expression of proteins that belong to two distinct gene regulatory networks, namely a cyclin-dependent kinases (Cdks) network driving the cell cycle and a cell transformation network which can undergo an epigenetic switch between a non-transformed and a malignant transformed cell state. Using mathematical modeling and transcriptomic data analysis, we here investigate how Let-7 contr...

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Literature Corpus work: a86e019e-5593-5978-95b1-86ed3751ff05
DOI: 10.1101/519165

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