Article

Tissue Specific Knockout of the Cardiolipin Transacylase Enzyme TAFAZZIN in Both Liver and Pancreatic Beta Cells Protects Mice From Diet-Induced Obesity

2022-04-19

Abstract excerpt

Mutations in the TAFAZZIN gene result in the X-linked genetic disease Barth Syndrome. The protein product tafazzin is a transacylase enzyme that remodels the phospholipid cardiolipin with fatty acids. Some Barth syndrome boys exhibit a lean phenotype. In addition, whole body knockdown of tafazzin in mice protects them from diet-induced obesity through increased hepatic fatty acid oxidation and reduced basal insuli...

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Literature Corpus work: a8269f49-1510-5475-8511-80c2cb0c2684
DOI: 10.1101/2022.04.19.488810

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