Article

Activity-dependent coupling of axonal amphisome trafficking and local norepinephrine signaling <i>in vivo</i>

2025-09-25

Abstract excerpt

<h4>ABSTRACT</h4> Amphisomes are autophagy-related organelles formed by the fusion of autophagosomes with late endosomes. In neurons, they contribute to both cargo degradation and signaling, yet their physiological roles in vivo remain unclear. Here, we show that axonal amphisome trafficking in highly branched locus coeruleus ( LC ) neurons is regulated by neuronal activity, novelty-associated behavioral state,...

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Literature Corpus work: a810ac1e-bcaa-520c-bf4b-9a83725fb643
DOI: 10.1101/2025.09.23.677999

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