Article

FLNB and TTC26 target ciliary hedgehog signaling to mediate extracellular matrix homeostasis of intervertebral disc in adolescent idiopathic scoliosis Running Title：FLNB and TTC26 regulate ntervertebral disc degeneration

2024-12-16

Abstract excerpt

<title>Abstract</title> <p> Variable recurrence risk and curve manifestations in adolescent idiopathic scoliosis (AIS) has been ascribed to the oligogenic effect of multiple genes. However, evidence to support this hypothesis is currently lacking. In this study, we generated mice carrying double heterozygous mutations by injecting mouse androgenic haploid embryonic stem cells with mutant <italic>Flnb</italic>...

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Literature Corpus work: a7cda364-6fd4-5165-b133-ba22f75db674
DOI: 10.21203/rs.3.rs-5410799/v1

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FLNB and TTC26 target ciliary hedgehog signaling to mediate extracellular matrix homeostasis of intervertebral disc in adolescent idiopathic scoliosis Running Title：FLNB and TTC26 regulate ntervertebral disc degenerationDOI 10.21203/rs.3.rs-5410799/v1Read

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