A mathematical description of non-self for biallelic genetic systems in pregnancy, transfusion, and transplantation

Abstract excerpt

A central issue in immunology is the immunological response against non-self. The prerequisite for a specific immunological response is the exposure to the immune system of a non-self-antigen. Mathematical equations are presented, that define the fraction of all outcomes with a non-self-allele in biallelic systems at the population level in pregnancy and transfusion/transplantation medicine. When designing assays,...

Topics

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• Alleles
• Blood groups and transfusion
• Blood Transfusion
• Models, Theoretical
• Organ Transplantation Techniques and Outcomes
• Pregnancy
• Prenatal Screening and Diagnostics
• Renal Transplantation Outcomes and Treatments

Identifiers and source

Literature Corpus work

a7b1d0ae-86bb-58bf-877a-7f8247543407

DOI

10.1101/2024.04.10.588831