Non-inherited maternal antigens, pregnancy, and allotolerance

doi:10.4103/2319-4170.143498

Article

Non-inherited maternal antigens, pregnancy, and allotolerance

28 Oct 2014

Abstract excerpt

Non-inherited maternal antigens (NIMA) are those protein products derived from polymorphic genes that the mothers express but not the offspring. During normal human pregnancy, a bidirectional regulation occurs in such a way that the maternal immune system tolerates the inherited paternal antigens (IPA) expressed by the fetus and the developing fetal immune system tolerates NIMA. The process by which the described...

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