Article
Virulence plasmids of enteroinvasive Escherichia coli and Shigella flexneri integrate into a specific site on the host chromosome: integration greatly reduces expression of plasmid-carried virulence genes.
Infection and immunity - 1 Mar 1991
Zagaglia C, Casalino M, Colonna B, Conti C, Calconi A, Nicoletti M
Abstract excerpt
The ability of enteroinvasive Escherichia coli and Shigella flexneri to cause disease depends on the presence of a large virulence plasmid (pINV). In this report we show that pHN280, the pINV of the O135:K-:H- enteroivasive strain E. coli HN280, and pWR100, the pINV of S. flexneri serotype 5 stra...
Topics
- Animals
- Blotting, Western
- Chromosomes
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Guinea Pigs
- HeLa Cells
- Keratoconjunctivitis
- Methionine
- Mutagenesis, Site-Directed
- Phenotype