Article
Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system.
mBio - 5 Feb 2025
Hollingshead Sarah, McVicker Gareth, Nielsen Maria R, Zhang YuGeng, Pilla Giulia, Jones Rebekah A, Thomas Jonathan C, Johansen Sarah E H, Exley Rachel M, Brodersen Ditlev E, Tang Christoph M
Abstract excerpt
Toxin:antitoxin (TA) systems are widespread in bacteria and were first identified as plasmid addiction systems that kill bacteria lacking a TA-encoding plasmid following cell division. TA systems have also been implicated in bacterial persistence and antibiotic tolerance, which can be precursors of antibiotic resistance. Here, we identified a clinical isolate of Shigella sonnei (CS14) with a remarkably stable...
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