Article

Somatic aberrations of BRCA1 gene are associated with progressive and stem cell-like phenotype of prostate cancer

2018-02-26

Abstract excerpt

<h4>Background</h4> BRCA1 is a pivotal tumor suppressor. Its dysfunction is known to play a role in different tumor entities. Among others, BRCA1 germline mutations account for higher risk and more aggressive course of prostate cancer (PCa). In addition, somatic BRCA1 gene loss was demonstrated to be a signature of PCa dissemination to regional lymph nodes and peripheral blood, and indicate worse clinical outcome...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a724e4d1-2490-5948-8986-f54504485b06
DOI: 10.1101/271312

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Somatic aberrations of BRCA1 gene are associated with progressive and stem cell-like phenotype of prostate cancerDOI 10.1101/271312Read

ALDH1-positive intratumoral stromal cells indicate epithelial differentiation and good prognosis in prostate cancerSemantic proximity Read

The distinct role of ALDH1A1 and ALDH1A3 in the regulation of prostate cancer metastasesSemantic proximity Read

BRCA1 as a potential human prostate tumor suppressor: modulation of proliferation, damage responses and expression of cell regulatory proteinsSemantic proximity Read

Prolyl 4-hydroxylase subunit beta (P4HB) could serve as a prognostic and radiosensitivity biomarker for prostate cancer patientsSemantic proximity Read

Tumor protein expression of the DNA repair gene BRCA1 and lethal prostate cancer.Semantic proximity Read

Dach1-Variant 4 Plays an Oncogenic Role and Promotes Radioresistance in Prostate CancerSemantic proximity Read

BRCA1 and EZH2 cooperate in regulation of prostate cancer stem cell phenotypeSemantic proximity Read

Identification of novel CHD1-associated collaborative alterations of genomic structure and functional assessment of CHD1 in prostate cancer.Semantic proximity Read

Genomic and epigenomic analysis of plasma cell-free DNA identifies stemness features associated with worse survival in<i>AR</i>-altered lethal prostate cancerSemantic proximity Read

Molecular classification of prostate cancer using curated expression signaturesSemantic proximity Read

Annexin A1 is involved in the acquisition and maintenance of a stem cell-like/aggressive phenotype in prostate cancer cells with acquired resistance to zoledronic acid.Semantic proximity Read

Blood-based detection of MMP11 as a marker of prostate cancer progression regulated by the ALDH1A1-TGF-β1 signaling mechanismSemantic proximity Read