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Article

Annexin A1 is involved in the acquisition and maintenance of a stem cell-like/aggressive phenotype in prostate cancer cells with acquired resistance to zoledronic acid.

Oncotarget - 22 Sept 2015

Bizzarro Valentina, Belvedere Raffaella, Milone Maria Rita, Pucci Biagio, Lombardi Rita, Bruzzese Francesca, Popolo Ada, Parente Luca, Budillon Alfredo, Petrella Antonello

Abstract excerpt

In this study, we have characterized the role of annexin A1 (ANXA1) in the acquisition and maintenance of stem-like/aggressive features in prostate cancer (PCa) cells comparing zoledronic acid (ZA)-resistant DU145R80 with their parental DU145 cells. ANXA1 is over-expressed in DU145R80 cells and its down-regulation abolishes their resistance to ZA. Moreover, ANXA1 induces DU145 and DU145R80 invasiveness acting...

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Source

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Identifiers

PMID: 26312765
DOI: 10.18632/oncotarget.4725
PMCID: PMC4694816

Genes

ANXA1
ABCG2
NANOG
STAT3

Provenance

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Annexin A1 is involved in the acquisition and maintenance of a stem cell-like/aggressive phenotype in prostate cancer cells with acquired resistance to zoledronic acid.PMID 26312765Read ↗

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