Article

Preferential innervation of endometriosis by hyperexcitable Ret/GFRα1+ nociceptors associates with target GDNF and clinical pain

2026-08-26

Abstract excerpt

Endometriosis is a prevalent condition characterized by chronic pelvic pain that is frequently refractory to treatment. While the mechanisms underlying this pain remain poorly defined, clinical evidence often indicates that lesion innervation, but not disease stage (e.g. number and depth of lesions), correlate with pelvic pain severity. However, characterization of lesion-innervating neurons is incomplete, reveali...

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Literature Corpus work: a6f58ef9-6721-598b-89c3-e000574e9a44
DOI: 10.64898/2026.08.21.744503

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