Article

Pro-endometriosis macrophage release of IL-33 is key for endometriosis pain and lesion formation

2025-10-21

Abstract excerpt

<h4>ABSTRACT</h4> Endometriosis is a painful gynecological inflammatory disease affecting up to 10% of females. When released by sensory neurons, calcitonin gene-related peptide (CGRP) shapes immunity, a process known as neuroimmune communication. We previously showed that nociceptor-derived CGRP polarizes macrophages into pro-endometriosis macrophages (PEMs) that mediates endometrial epithelial (endo-epi) cell p...

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Literature Corpus work: 4b13419e-f15d-59fb-85e9-52cd0d54468e
DOI: 10.1101/2025.10.20.683510

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