Article

Kinetic stabilization of translation-repression condensates by a neuron-specific microexon

2023-03-22

Abstract excerpt

The inclusion of microexons by alternative splicing is frequent in neuronal proteins. The roles of these sequences are in most cases unknown, but changes in their degree of inclusion are associated with neurodevelopmental diseases. We recently found that the decreased inclusion of a 24-nucleotide neuron-specific microexon in CPEB4, an RNA-binding protein that regulates translation through cytoplasmic changes in po...

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Literature Corpus work: a6eec639-619e-5834-9b44-f5ed43e2c222
DOI: 10.1101/2023.03.19.532587

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