Article

Selective IgA<sub>2</sub>deficiency in a patient with small intestinal Crohn’s disease

2022-12-07

Abstract excerpt

The human IgA response is composed of two structurally different subclasses termed IgA 1 and IgA 2 . Compared to IgA 1 , IgA 2 has a shorter hinge region, which makes it more resistant to bacterial proteases. IgA 1 is produced both systemically and in mucosal surfaces, whereas IgA 2 is mostly confined to the intestines. While the overall IgA response is known to be involved in intestinal homeostasis, the specific...

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Literature Corpus work: a6e05ead-43cc-58c6-8f98-363ba7648de6
DOI: 10.1101/2022.12.03.22282315

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