Article

DNA Methylation Differences Stratified by Normalized Fetal/Placental Weight Ratios Suggest Neurodevelopmental Deficits in Neonates with Congenital Heart Disease

2025-01-10

Abstract excerpt

<h4>Background</h4> We lack early biomarkers for predicting neurodevelopment (ND) outcomes in children with congenital heart disease (CHD). Placentas of fetuses with CHD have abnormalities, including unbalanced fetal/placental weight ratios (F/P). Although DNA methylation profiles have revealed insights into the maternal-fetal environment (MFE), it is unknown if DNA methylation correlates to normalized F/P weight...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a6b59d9c-bd1a-5973-b76d-4bc539250cf9
DOI: 10.1101/2025.01.08.25320236

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA Methylation Differences Stratified by Normalized Fetal/Placental Weight Ratios Suggest Neurodevelopmental Deficits in Neonates with Congenital Heart DiseaseDOI 10.1101/2025.01.08.25320236Read

DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight.Semantic proximity Read

Epigenomic signatures of accelerated epigenetic aging are associated with congenital heart disease in newbornsSemantic proximity Read

Multiomic Investigation of Shared Genetic Pathways in Paediatric Congenital Heart Disease and Neurodevelopmental Disorders.Semantic proximity Read

Serious neonatal morbidities are associated with differences in DNA methylation among very preterm infantsSemantic proximity Read

Placental epigenetics for evaluation of fetal congenital heart defects: Ventricular septal defect (VSD)Semantic proximity Read

Epigenomic signature of major congenital heart defects in newborns with Down syndromeSemantic proximity Read

Neonatal Genome-Wide Methylation Patterns in Relation to Birth Weight in the Norwegian Mother and Child CohortSemantic proximity Read

Placental epigenetics for evaluation of fetal congenital heart defects: Ventricular Septal Defect (VSD)Semantic proximity Read

Maternal Genome-Wide DNA Methylation Patterns and Congenital Heart DefectsSemantic proximity Read

3rd Trimester Umbilical Arterial Pulsatility Index Is Associated with Neurodevelopmental Outcomes at 2-years in Major Congenital Heart Disease.Semantic proximity Read

Structural covariance networks in the fetal brain reveal altered neurodevelopment for specific subtypes of congenital heart diseaseSemantic proximity Read