Article
A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells
2019-10-22
Abstract excerpt
Clinical translation of human pluripotent stem cells (hPSCs) requires advanced strategies that ensure safe and robust long-term growth and functional differentiation. Pluripotent cells are capable of extensive self-renewal, yet remain highly sensitive to environmental perturbations in vitro , posing challenges to their therapeutic use. Here, we deployed innovative high-throughput screening strategies to identify...
Topics
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- CAR-T cell therapy research
- Chemotherapy-induced cardiotoxicity and mitigation
- Chemotherapy-induced organ toxicity mitigation
- CRISPR and Genetic Engineering
- Cytomegalovirus and herpesvirus research
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Virus-based gene therapy research
Identifiers and source
- Literature Corpus work
- a6b4bbc8-ca1e-58fb-83c6-79d007f863ac
- DOI
- 10.1101/815761
