“Less is more”: a dose-response account of intranasal oxytocin pharmacodynamics in the human brain

Abstract excerpt

Intranasal oxytocin is receiving increasing research attention as a potential treatment for several brain disorders due to promising preclinical results. However, translating these findings to humans has been hampered by remaining uncertainties about its pharmacodynamics and the methods used to probe its effects in the human brain. Using a dose-response design (9, 18 and 36 IU) and a novel administration device, w...

Topics

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• Administration, Intranasal
• Amygdala
• Double-Blind Method
• Emotions
• Genotype
• Magnetic Resonance Imaging
• Oxytocin
• Receptors, Oxytocin

Identifiers and source

Literature Corpus work

a68dafbd-e97b-5c6b-865b-b5842f75b81b

DOI

10.1101/2021.01.18.427062