Article

Effects of exogenous oxytocin on human brain function are regulated by oxytocin gene expression: a meta-analysis of 20 years of oxytocin neuroimaging and transcriptomic analyses

2025-08-26

Abstract excerpt

Over the past two decades, numerous pharmaco-imaging studies have explored the neural basis of oxytocin (OT) on human cognition and behavior, yet findings are heterogenous and the links between the macroscopic neurofunctional effects and microscopic organization of the brain remain unclear. Here, we systematically explored the general neuromodulatory effects of OT across behavioral domains and populations by combi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93bfdb01-a661-5643-91fc-30341b8cb682
DOI: 10.1101/2025.08.24.25334303

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effects of exogenous oxytocin on human brain function are regulated by oxytocin gene expression: a meta-analysis of 20 years of oxytocin neuroimaging and transcriptomic analysesDOI 10.1101/2025.08.24.25334303Read

Oxytocin gene networks in the human brain: A gene expression and large-scale fMRI meta-analysis studySemantic proximity Read

Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in womenSemantic proximity Read

“Less is more”: a dose-response account of intranasal oxytocin pharmacodynamics in the human brainSemantic proximity Read

A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function.Semantic proximity Read

Single Dose Intranasal Oxytocin Administration: Data from Healthy Younger and Older AdultsSemantic proximity Read

A common oxytocin receptor gene (OXTR) polymorphism modulates intranasal oxytocin effects on the neural response to social cooperation in humans.Semantic proximity Read

Oxytocin Pathway Genes: Evolutionary Ancient System Impacting on Human Affiliation, Sociality, and Psychopathology.Semantic proximity Read

Oxytocin receptor gene variations predict neural and behavioral response to oxytocin in autism.Semantic proximity Read

Parallel social information processing circuits are differentially impacted in autismSemantic proximity Read

The central renin angiotensin II system – a genetic pathway, functional decoding and selective target engagement characterization in humansSemantic proximity Read

Human neuroimaging of oxytocin and vasopressin in social cognition.Semantic proximity Read

Dissociable neurofunctional and molecular characterizations of reward and punishment sensitivitySemantic proximity Read