Article

Epigenetics and Familial Hypercholesterolemia: a methylation study on the three canonical genes

2022-12-29

Abstract excerpt

<title>Abstract</title><p>Familial hypercholesterolemia (FH) is characterized by high low-density lipoprotein cholesterol (LDL-C) levels and a high risk of early coronary heart disease. Structural alterations in the<italic>LDLR</italic>,<italic>APOB</italic>, and<italic>PCSK9</italic>genes were not found in 20–40% of patients diagnosed using the Dutch Lipid Clinic Network (DCLN) criteria. We hypothesized that meth...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a620a8eb-266d-5f5c-9310-76f56501df48
DOI: 10.21203/rs.3.rs-2268996/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenetics and Familial Hypercholesterolemia: a methylation study on the three canonical genesDOI 10.21203/rs.3.rs-2268996/v1Read

LDLR gene's promoter region hypermethylation in patients with familial hypercholesterolemia.Semantic proximity Read

Genetic polymorphisms in LDLR, APOB, PCSK9 and other lipid related genes associated with familial hypercholesterolemia in Malaysia.Semantic proximity Read

Differential DNA methylation in familial hypercholesterolemia.Semantic proximity Read

Epipolymorphisms within lipoprotein genes contribute independently to plasma lipid levels in familial hypercholesterolemiaSemantic proximity Read

In silico analysis of upstream variants in Brazilian patients with Familial hypercholesterolemia.Semantic proximity Read

APOA1/C3/A4/A5 Gene Cluster at 11q23.3 and Lipid Metabolism Disorders: From Epigenetic Mechanisms to Clinical PracticesSemantic proximity Read

A genetic variant in the LDLR promoter is responsible for part of the LDL-cholesterol variability in primary hypercholesterolemia.Semantic proximity Read

Epigenome-Wide Analysis in Familial Hypercholesterolemia Identified New Loci Associated with High-Density Lipoprotein Cholesterol ConcentrationSemantic proximity Read

Fenotipo de hipercolesterolemia familiar definitivo con estudio genético negativo en Argentina.Semantic proximity Read

A new PCSK9 gene promoter variant affects gene expression and causes autosomal dominant hypercholesterolemia.Semantic proximity Read

ABCA1 gene promoter DNA methylation is associated with HDL particle profile and coronary artery disease in familial hypercholesterolemia.Semantic proximity Read

Possible explanations for the common clinical familial hypercholesterolemia phenotypes in the Faroe Islands.Semantic proximity Read