Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ABCA1 gene promoter DNA methylation is associated with HDL particle profile and coronary artery disease in familial hypercholesterolemia.

Epigenetics - 1 May 2012

Guay Simon-Pierre, Brisson Diane, Munger Johannie, Lamarche Benoit, Gaudet Daniel, Bouchard Luigi

Abstract excerpt

High-density lipoproteins cholesterol (HDL-C) level, a strong coronary artery disease (CAD) clinical biomarker, shows significant interindividual variability. However, the molecular mechanisms involved remain mostly unknown. ATP-binding cassette A1 (ABCA1) catalyzes the cholesterol transfer from peripheral cells to nascent HDL particles. Recently, a differentially methylation region was identified in ABCA1 gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter 1
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol, HDL

Share to Coronary Artery Disease

Share to Genetic Loci

Share to Hyperlipoproteinemia Type II

Share to Nucleotide Motifs

Share to Receptors, LDL

Source

Identifiers

PMID: 22419126
DOI: 10.4161/epi.19633

Genes

ABCA1
CAD
LDLR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ABCA1 gene promoter DNA methylation is associated with HDL particle profile and coronary artery disease in familial hypercholesterolemia.PMID 22419126Read ↗

A preliminary study of the association between the ABCA1 gene promoter DNA methylation and coronary artery disease risk.Semantic proximity Read ↗

DNA Methylation of Lipid-Related Genes Affects Blood Lipid LevelsSemantic proximity Read ↗

Epipolymorphisms within lipoprotein genes contribute independently to plasma lipid levels in familial hypercholesterolemiaSemantic proximity Read ↗

Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies.Semantic proximity Read ↗

Association of lipid metabolism-related gene promoter methylation with risk of coronary artery disease.Semantic proximity Read ↗

Association of Lipid Metabolism Related Gene Promoter Methylation with Risk of Coronary Artery DiseaseSemantic proximity Read ↗

A novel haplotype in ABCA1 gene effects plasma HDL-C concentration.Semantic proximity Read ↗

Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels.Semantic proximity Read ↗

Differential DNA methylation in familial hypercholesterolemia.Semantic proximity Read ↗

Association of ATP-binding cassette transporter A1 gene polymorphisms with plasma lipid variability and coronary heart disease risk.Semantic proximity Read ↗

Epigenome-Wide Analysis in Familial Hypercholesterolemia Identified New Loci Associated with High-Density Lipoprotein Cholesterol ConcentrationSemantic proximity Read ↗

Overall and sex-specific associations between methylation of the ABCG1 and APOE genes and ischemic stroke or other atherosclerosis-related traits in a sibling study of Chinese populationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.