Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential DNA methylation in familial hypercholesterolemia.

EBioMedicine - 1 Nov 2020

Reeskamp Laurens F, Venema Andrea, Pereira Joao P Belo, Levin Evgeni, Nieuwdorp Max, Groen Albert K, Defesche Joep C, Grefhorst Aldo, Henneman Peter, Hovingh G Kees

Abstract excerpt

BACKGROUND: Familial hypercholesterolemia (FH) is a monogenic disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C). A FH causing genetic variant in LDLR, APOB, or PCSK9 is not identified in 12-60% of clinical FH patients (FH mutation-negative patients). We aimed to assess whether altered DNA methylation might be associated with FH in this latter group. METHODS: In this study we included...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ROC Curve
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Epigenomics

Share to Hyperlipoproteinemia Type II

Share to Machine Learning

Source

Open in PubMed Open full text

Identifiers

PMID: 33096472
DOI: 10.1016/j.ebiom.2020.103079
PMCID: PMC7581877

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential DNA methylation in familial hypercholesterolemia.PMID 33096472Read ↗

Epigenome-Wide Analysis in Familial Hypercholesterolemia Identified New Loci Associated with High-Density Lipoprotein Cholesterol ConcentrationSemantic proximity Read ↗

Genomics, epigenomics and pharmacogenomics of familial hypercholesterolemia (FHBGEP): A study protocolSemantic proximity Read ↗

Genetic polymorphisms in LDLR, APOB, PCSK9 and other lipid related genes associated with familial hypercholesterolemia in Malaysia.Semantic proximity Read ↗

Familial Hypercholesterolemia Identification by Machine Learning Using Lipid Profile Data Performs as Well as Clinical Diagnostic Criteria.Semantic proximity Read ↗

Epipolymorphisms within lipoprotein genes contribute independently to plasma lipid levels in familial hypercholesterolemiaSemantic proximity Read ↗

Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies.Semantic proximity Read ↗

A machine learning model to aid detection of familial hypercholesterolaemiaSemantic proximity Read ↗

Prevalence of FH-Causing Variants and Impact on LDL-C Concentration in European, South Asian, and African Ancestry Groups of the UK Biobank—Brief ReportSemantic proximity Read ↗

Targeted Genetic Analysis in a Chinese Cohort of 208 Patients Related to Familial Hypercholesterolemia.Semantic proximity Read ↗

LDLR gene's promoter region hypermethylation in patients with familial hypercholesterolemia.Semantic proximity Read ↗

Molecular Screening of Familial Hypercholesterolemia in the Icelandic PopulationSemantic proximity Read ↗

Whole exome sequencing of familial hypercholesterolaemia patients negative for LDLR/APOB/PCSK9 mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.