The proteomic landscape and temporal dynamics of mammalian gastruloid development

Abstract excerpt

<h4>ABSTRACT</h4> Gastrulation is the process by which the early embryo establishes a body plan and primes itself for organogenesis. As gastrulation is challenging to study in vivo , stem cell-derived “gastruloids” have emerged as powerful surrogates. Although transcriptomics and imaging have been applied extensively to such embryo models, the dynamics of their proteomes remains largely unknown. Here, we apply q...

Topics

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• Brain
• Embryo, Mammalian
• Gastrulation
• Gene Expression Regulation, Developmental
• Organ Specificity
• Organogenesis
• Single-Cell Gene Expression Analysis
• Transcriptome

Identifiers and source

Literature Corpus work

a61590aa-6642-5310-8323-cce683f3a9d8

DOI

10.1101/2024.09.05.609098