Article

Reduced cellular diversity and an altered basal progenitor cell state inform epithelial barrier dysfunction in human type 2 immunity

2017-11-14

Abstract excerpt

<h4>ABSTRACT</h4> Tissue barrier dysfunction is a poorly defined feature hypothesized to drive chronic human inflammatory disease 1,2 . The epithelium of the upper respiratory tract represents one such barrier, responsible for separating inhaled agents, such as pathogens and allergens, from the underlying submucosa. Specialized epithelial subsets—including secretory, glandular, and ciliated cells—differentiate f...

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Literature Corpus work: 48ea5746-71e5-5247-95bb-5190b5a46434
DOI: 10.1101/218958

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