Article
The global transcriptomic signature in sinonasal tissues reveals roles for tissue type and chronic rhinosinusitis disease phenotype.
Rhinology - 1 Jun 2020
Bassiouni A, Ou J, Schreiber A, Geoghegan J, Tsykin A, Psaltis A J, Wormald P-J, Vreugde S
Abstract excerpt
BACKGROUND: RNA sequencing (RNA-Seq) allows the characterization of a global transcriptomic signature in a least-biased fashion, but few studies have applied this method to investigate the pathophysiology of CRS. METHODS: We collected mucosal tissue samples from 6 CRS without nasal polyps (CRSsNP), 6 CRS with nasal polyps (CRSwNP), and 6 control patients. Additional matched polyp samples were collected from the 6...
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